Andres Kriete

Systems Biology is concerned with the quantitative study of complex biosystems at the molecular, cellular, tissue, and systems scales. Its focus is on the function of the system as a whole, rather than on individual parts. This exciting new arena applies mathematical modeling and engineering methods to the study of biological systems. This book is the first of its kind to focus on the newly emerging field of systems biology with an emphasis on computational approaches. The work covers new concepts, methods for information storage, mining and knowledge extraction, reverse engineering of gene and metabolic networks, as well as modelling and simulation of multi-cellular systems. Central themes include strategies for predicting biological properties and methods for elucidating structure-function relationships.

This book is a guide to biomedical visualization in microscopy, a new method of computer-aided three-dimensional imaging. Aspects of computer graphics, image analysis, specimen preparation, and microscopy technology are combined in this multiauthored work to provide thorough coverage of the most important biomedical applications of visualization. Examples include three-dimensional imaging of serial mechanical sections in light and electron microscopy as well as non-invasive sections in microtomography and confocal microscopy. Special emphasis is placed on advanced 3-D imaging with laser scanning microscopes. An exciting new technique presented here is four-dimensional visualization: the time- resolved imaging of in-vivo microstructures.
Serving as an excellent introductory text and reference source for microscopists, computer scientists, and researchers in biology and clinical medicine, this book also contains over 150 illustrations, many in color, as well as a fold-out poster of a computer-generated image of cell mitosis.